1. Bo Burnham
Bo Burnham got his start on YouTube in the late 2000s, posting videos of himself singing in his bedroom. Since then, he's gone on to perform in multiple comedy tours and even had his own show on MTV. Though Burnham's popularity has grown substantially and his YouTube account has been relatively inactive for a few years, he recently posted (in full) his most recent stand up special: What. He has also gained an extensive following on Vine. Search "Top Vines", you're bound to see one or two Bo Burnham clips.
2. Mike Birbiglia
Mike Birbiglia's Twitter account is a diamond in the rough. While most comedians use their social media pages almost exclusively to promote their own work, Birbiglia's account is full of funny quips about his own life and his frustrations with Twitter. He still uses his page to promote his work, but scrolling down his feed, his personal posts far outnumber promotions. Also, in his act he talks about how he uses social media to read about himself. Mike, if you're reading, watch out for the jackal!
3. Reggie Watts
Reggie Watts is widely known for his musical comedy style. If you haven't heard of him, you can get a feel for his work by watching his amazingly nonsensical Ted talk. If you have heard of him and want to get an idea of how he represents himself on social media, take a look at his Vine account. Most of his vines aren't even of himself, but are rather montages of scenery or pieces of his day. From time to time, he even posts backstage shots of his TV show Comedy Bang Bang.
4 & 5. Mindy Kaling and B.J. Novak
You probably know Kaling and Novak from their days on NBC's The Office. However their relationship stretches far beyond the walls of Dunder Mifflin. The two are real life friends, and looking at their Instagram and Twitter accounts prove it. Check out their amazingly fun to read back and fourths. These two actually use social media to be, you know, social.